cyclosporine will increase the stage or impact of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.elvitegravir/cobicistat/emtricitabine/tenofovir DF boosts amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.primidone will lower the extent or influence of bortezomib by influencing