cyclosporine will increase the stage or impact of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
elvitegravir/cobicistat/emtricitabine/tenofovir DF boosts amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
primidone will lower the extent or influence of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
There are stories of existence-threatening graft vs . host disease in sufferers with myeloma getting therapy with bortezomib. So, all clients with many myeloma and lymphoma ought to acquire irradiated blood solutions to lessen this threat.
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stiripentol will raise the amount or impact of bortezomib by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Closely. Take into account decreasing the dose of CYP2C19 substrates, if adverse reactions are expert when administered concomitantly with stiripentol.
fosphenytoin will minimize the extent or result of bortezomib Lin281632 by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
tecovirimat will enhance the stage or result of bortezomib by affecting hepatic enzyme CYP2C19 Dup 747 metabolism. Use Warning/Keep track of. Tecovirimat is actually a weak inhibitor of CYP2C8 and CYP2C19. Keep track of for adverse results if coadministered with sensitive substrates of such enzymes.
bortezomib will raise the stage or impact of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of moderate CYP3A4 inhibitors with midazolam intranasal might lead to better midazolam systemic publicity, which can lengthen sedation.
danazol will raise the degree or result of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.
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The drug is metabolized by the CYP3A4 and CYP2C19 enzymes while in the liver. The metabolites are inactive and are excreted via the kidney.
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oxcarbazepine will lower the level or impact of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.